منابع مشابه
Neomycin-neomycin dimer: an all-carbohydrate scaffold with high affinity for AT-rich DNA duplexes.
A dimeric neomycin-neomycin conjugate 3 with a flexible linker, 2,2'-(ethylenedioxy)bis(ethylamine), has been synthesized and characterized. Dimer 3 can selectively bind to AT-rich DNA duplexes with high affinity. Biophysical studies have been performed between 3 and different nucleic acids with varying base composition and conformation by using ITC (isothermal calorimetry), CD (circular dichro...
متن کاملMolecular recognition of RNA by neomycin and a restricted neomycin derivative.
several other RNA motifs form well-defined complexes with individual aminoglycosides, which makes these antibiotics excellent model ligands for the study of RNA recognition. The target “promiscuity” of the aminoglycosides has been attributed to two major factors: 1) their highly charged nature, which is responsible for their eletrostatically driven RNA-binding mode and 2) their conformational a...
متن کاملStability of neomycin resistance in Staphylococcus aureus.
A strain of Staphylococcus aureus isolated from the skin of a subject with eczema showed a loss in resistance to neomycin and tetracycline after treatment with neomycin was stopped. Seven out of 22 strains of neomycin-resistant Staph. aureus showed a loss in resistance to neomycin and streptomycin after storage in nutrient broth for 14 days at room temperature, and it seems probable that resist...
متن کاملMitsunobu dehydration of N-Boc neomycin B.
Reaction of hexa-N-Boc neomycin B with TPP and DIAD in toluene results in the formation of an epoxide in ring IV, not an aziridine or azetidine as previously reported.
متن کاملThe Production of Neomycin by Streptomyces Fradiae
Of basic importance to the study of antibiotic production by microorganisms is a chemically defined medium in which the effect of various nutrients, both organic and inorganic, can be studied with a minimum of interference from ill-defined substances. Such a medium is reported here for the production of neomycin by Streptomyces fradiae, together with studies on the influence of various nitrogen...
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ژورنال
عنوان ژورنال: American Journal of Public Health and the Nations Health
سال: 1953
ISSN: 0002-9572
DOI: 10.2105/ajph.43.7.924-b